The likes of Diogo Dalot Eric Bailly, Phil Jones and Ashley Young return to the side that faces Derby County, with Dalot making his first appearance at Old Trafford for Manchester United.
Pogba has already informed executive vice-chairman Ed Woodward of his desire to leave but Woodward remains determined to keep the £89 million World Cup victor.
The midfielder has skippered the club three times this season and has been considered vice-captain by Mourinho.
This defeat will only worsen an already tense atmosphere at Old Trafford, as well as within the dressing room. ‘Obviously going down to 10 men is not easy.
“Then penalties come and someone has to miss”.
Speaking after the game, Mourinho noted that he told his players to be wary of a Derby resurgence at half time.
“We are at home and we should play much better against Wolves”.
Mourinho is now priced at just 6/4 (William Hill) to be the first victim of the 2017/18 Premier League, while he’s 8/1 to be axed prior to United’s next game away to West Ham on Saturday, and 4/7 to be gone before Christmas.
United had taken the lead in the third minute with a well-placed shot from Juan Mata after Anthony Martial had burst down the left flank.
The 25-year-old infuriated Mourinho after the Wolves match when he insisted United should “attack, attack, attack” in what was perceived as a dig at the manager’s conservative tactics.
“Our board, our investors and everyone at the club are aligned with the fans on what we need to do on the pitch – and that is to win trophies”, Woodward told investors on Tuesday.
‘I think they had more intensity than we did. When you’re playing these games, you have to show that intensity and go further than the opposition. I am so proud of them.
‘When you don’t take your chances, you can get punished.
Middlesbrough progressed 4-3 on penalties after a 2-2 draw with Preston and League One Blackpool beat Championship strugglers QPR 2-0.
United, under manager Jose Mourinho, are seventh in the Premier League after a disappointing start to the season, eight points behind leaders Liverpool and six behind reigning champions Manchester City.
Tuesday proved to a busy day at Old Trafford, where record-breaking revenues were quickly overshadowed by fresh questions over the club-record signing and a shock cup exit.